Dual Career Fellowships
In an effort to support dual career couples, the CHS foundation funded several fellowships:
Clinical outcomes of Zika virus infection in children
Universitätsklinikum Heidelberg, Zentrum für Infektiologie
I study the epidemiology of arbovirus infections, mainly Zika, dengue and chikungunya. As part of the ZikAlliance consortium, our group is the clinical science leader of two multicentre cohorts established in 9 countries in Latin America and the French Caribbean to study Zika virus infection and its outcomes in pregnant women and their children.
The generation of clinical-grade human iPSC in a chemically-defined medium
Universität Heidelberg, Institut für Anatomie und Zellbiologie
Most iPSC have cancerous epigenetic profiles and are not usable for clinical applications. Special reprogramming techniques generate high quality iPSC with an epigenetic profile close to true ESC but require special feeder cells. I develop a chemically-defined medium to generate high quality human iPSC in xeno- and feeder-free conditions for clinical applications.
Deep Learning-based automatic cancer diagnosis and prognosis
Luis Vale Silva
Universität Heidelberg, Bioquant, Institute of Pharmacy and Molecular Biotechnology IPMB
His research focuses on the development of Deep Learning-based automatic cancer diagnosis and prognosis systems. He uses research approaches from Imaging Genomics, the data fusion field combining data from high-throughput Genomics and medical imaging.
Epigenetic changes during neuronal differentiation and activity
Genome Biology Research Unit, EMBL
I am working in the lab of Min Noh at the EMBL, where I am studying the epigenetics of neuronal differentiation and activity. We are using neurons derived from human iPSCs and mouse ES cells to determine how chromatin remodeling proteins control gene transcription during neuronal differentiation and following neuronal activity. These studies could contribute to our understanding of how patterns of gene expression help to shape neuronal circuits and encode information.
Creation of a state-of-the-art mathematical model of a thalamic neuron which reproduces new thalamocortical signal encoding properties
Universität Heidelberg, Institut für Physiologie und Pathophysiologie
I use experimental and computational approaches to study neural coding in the thalamocortical system, with a focus on pathways between identified cell types in the cortex and different regions in the thalamus. Another parallel focus is understanding how particular functional properties of single neurons arise from the biophysical properties of ion channels that support membrane excitability. Recently, I have begun studying corticothalamic interactions in nociception.